Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition
Huarong Yang, Qing Li, Mingzhi Su, Fang Luo, Yahua Liu, Daoping Wang, Yanhua Fan
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayProtein kinase BApoptosisCancer cellCell growthCell cycleCancer researchIC50Cell cultureCancerCell cycle checkpointPharmacologyBiochemistryIn vitroBiologyInternal medicineMedicineGeneticsQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsSynthesis and biological activity