Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases
Ruidan Shen, Rory Crean, Sean Johnson, Shina Caroline Lynn Kamerlin, Alvan C. Hengge
Abstract
values of catalytic residues by nonchemical processes affords a means for nature to alter an enzyme's pH dependency by a less disruptive path than altering electrostatic networks around catalytic residues themselves.
Topics & Concepts
ChemistryResidue (chemistry)TyrosineProtein tyrosine phosphataseActive sitePopulationStereochemistryCatalysisAmino acidNucleophileBiochemistrySociologyDemographyProtein Tyrosine PhosphatasesATP Synthase and ATPases ResearchProtein Structure and Dynamics