The inhibition of rutin on Src kinase blocks high glucose-induced EGFR/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification
Liang Wu, Luqian Li, Xue Wang, Haixia Wu, Manman Li, Yuxin Wang, Pei Sheng, Xiaofei An, Ming Yan
Topics & Concepts
TransactivationDiabetic nephropathyMAPK/ERK pathwayPharmacologyRutinProto-oncogene tyrosine-protein kinase SrcKinaseChemistryMedicineCancer researchDiabetes mellitusEndocrinologyBiochemistryTranscription factorAntioxidantGeneChronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesBioinformatics and Genomic Networks