Human iPSC-Derived Neural Crest Stem Cells Exhibit Low Immunogenicity
Vera J. Mehler, Chris Burns, Hans J. Stauss, Robert J. Francis, Melanie Moore
Abstract
T cells or induce cytokine production. We show that this was not a result of any immunosuppressive features of iPSC-NCSCs, but rather more consistent with their non-immunogenic molecular phenotype. These results are encouraging for the potential future use of iPSC-NCSCs as a cellular therapy.
Topics & Concepts
ImmunogenicityNeural crestNeural stem cellStem cellCrestBiologyCell biologyImmunologyImmune systemPhysicsEmbryoQuantum mechanicsMesenchymal stem cell researchPluripotent Stem Cells ResearchRNA Interference and Gene Delivery