Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation
Rasha M. Hassan, Mona E. Aboutabl, Manuela Bozzi, Mohammed Farrag El‐Behairy, Ahmed M. El Kerdawy, Beatrice Sampaolese, Claudia Desiderio, Federica Vincenzoni, Francesca Sciandra, Iman A. Y. Ghannam
Topics & Concepts
ChemistryFenofibrateChalconeGemfibrozilAntioxidantPharmacologyIn vivoBiochemistryStereochemistryCholesterolMedicineBiologyBiotechnologyPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismAldose Reductase and Taurine