Synthesis of 2-Indolyl <i>C</i>-Glycoside Neopetrosins A and C and Congeners via Ni-Catalyzed Photoreductive Cross-Coupling
Yan Xia, Yingjie Wang, Zhaolun Zhang, Tayyab Gulzar, Yuqi Lin, Jing Wang, Dapeng Zhu, Biao Yu
Abstract
The synthesis of neopetrosins A and C, two 2-indolyl C -α- d -mannopyranosides, and their congeners has been realized via a direct Ni/photoredox-catalyzed reductive coupling of 3-methoxycarbonyl-2-iodo-1 H -indoles with pyranosyl bromides.
Topics & Concepts
ChemistryCatalysisCoupling (piping)Coupling reactionGlycosideStereochemistryCombinatorial chemistryOrganic chemistryMechanical engineeringEngineeringSynthesis of Indole DerivativesBioactive Compounds and Antitumor AgentsMicrobial Natural Products and Biosynthesis