Synthesis of precision antibody conjugates using proximity-induced chemistry
Yu Cao, Chenfei Yu, Kuan‐Lin Wu, Xuechun Wang, Dong Liu, Zeru Tian, Lijun Zhao, Xuexiu Qi, Axel Loredo, Anna Chung, Han Xiao
Abstract
Our pClick technology enables efficient, simple, and site-specific conjugation of various moieties to the existing native antibodies. This technology does not require antibody engineering or additional UV/chemical/enzymatic treatments, therefore providing a general, convenient strategy for developing novel antibody conjugates.
Topics & Concepts
Bioorthogonal chemistryConjugateAntibodyChemistryCombinatorial chemistryPeptideProtein engineeringBiochemistryClick chemistryEnzymeBiologyImmunologyMathematical analysisMathematicsMonoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer ResearchPeptidase Inhibition and Analysis