Chinese Multidisciplinary Expert Consensus on Immune Checkpoint Inhibitor-Based Combination Therapy for Hepatocellular Carcinoma (2023 Edition)
Xiufeng Liu, Yinying Lu, Weiping Zhou, Tao Peng, Jie Zhou, Huaqiang Bi, Xia Feng, Xiaoping Chen
Abstract
<b><i>Background:</i></b> Immune checkpoint inhibitor (ICI)-based combination therapy modalities for hepatocellular carcinoma (HCC) have achieved significant efficacy in clinical research and practice and have become the mainstay for the treatment of unresectable HCC. <b><i>Summary:</i></b> To better help clinicians use combination immunotherapy drugs and regimens rationally, effectively, and safely, the editorial board facilitated a discussion with multidisciplinary experts in the field, adopted the “Delphi” consensus formation method, and finally revised and completed the “<i>Chinese Multidisciplinary Expert Consensus on the Immune Checkpoint Inhibitors (ICIs)-Based Combination Therapy for Hepatocellular Carcinoma (2023 Edition)</i>” on the basis of the 2021 edition. <b><i>Key Messages:</i></b> This consensus primarily focuses on the principles and methods of clinical practice of combination therapy based on ICIs, aiming to summarize the recommendations for clinical application based on the latest research and expert experience and provide application guidance for clinicians.