Daratumumab in AL amyloidosis
Ashutosh Wechalekar, Vaishali Sanchorawala
Abstract
Light-chain amyloidosis has come far, with the first treatment getting regulatory approval in 2021. Daratumumab-based regimens achieve deep hematologic and organ responses, offering a new therapeutic backbone. Early identification, correct fibril typing, challenges of the very advanced patient, and lack of therapies to remove amyloid deposits remain under study, but are, as yet, elusive. We review the progress of treatment in AL amyloidosis, the impact of daratumumab, and the next steps after treatment.
Topics & Concepts
DaratumumabAL amyloidosisAmyloidosisMedicinePathologyMultiple myelomaDermatologyInternal medicineLenalidomideImmunologyAntibodyImmunoglobulin light chainAmyloidosis: Diagnosis, Treatment, OutcomesMyeloproliferative Neoplasms: Diagnosis and TreatmentDermatological and Skeletal Disorders