Engineering the Modular Receptor-Binding Proteins of<i>Klebsiella</i>Phages Switches Their Capsule Serotype Specificity
Agnieszka Łątka, Sébastien Lemire, Dennis Grimon, Dorien Dams, Barbara Maciejewska, Timothy K. Lu, Zuzanna Drulis‐Kawa, Yves Briers
Abstract
The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.
Topics & Concepts
BacteriophageMicrobiologySerotypeAntimicrobialVirologyAntibiotic resistancePhage therapyKlebsiellaBiologyEscherichia coliAntibioticsGeneticsGeneBacteriophages and microbial interactionsBacterial Genetics and BiotechnologyRNA and protein synthesis mechanisms