Bio-fabricated nanocomposite hydrogel with ROS scavenging and local oxygenation accelerates diabetic wound healing
Yajie Pu, Penghui Wang, Rong Yang, Xiaoyan Tan, Tianqi Shi, Juping Ma, Wenliang Xue, Bo Chi
Abstract
. Meanwhile, these SF-based hydrogels can offset the overexpression of matrix metalloproteinases (MMPs) in diabetic wounds (more than 80%) and promote remodeling of the extracellular matrix. Eventually, wound healing rates >76% in 7 days and 100% in 14 days were achieved by the bio-fabricated nanocomposite hydrogel and are remarkably faster than the commercial dressing healing rates (<30% in 7 days and <80% in 14 days). These results indicate that this bio-fabricated hydrogel system with multiple and customizable functions has great promise in the personalized clinical care of chronic wounds.
Topics & Concepts
NanocompositeMaterials scienceWound healingReactive oxygen speciesMatrix metalloproteinaseBiomedical engineeringNanotechnologyMedicineChemistrySurgeryBiochemistryInternal medicineWound Healing and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsNanoplatforms for cancer theranostics