AIE-active luminogens as highly efficient free-radical ROS photogenerator for image-guided photodynamic therapy
Zhenxing Liu, Qi Wang, Wanshan Qiu, Yanting Lyu, Zhirong Zhu, Xiaolei Zhao, Weihong Zhu
Abstract
electrostatic interactions to provide a light-up signal and kill bacteria at a low concentration. In the PDT treatment of bacteria-infected mice, the mice exhibited accelerated wound healing with low wound infection. Thus, the AIE-based type I photosensitizer TCM-CPS has great potential to replace commercially available photosensitizers in the image-guided PDT modality for the treatment of cancer and bacterial infection.
Topics & Concepts
PhotosensitizerPhotochemistryPhotodynamic therapySinglet oxygenChemistryFluorescenceRational designReactive oxygen speciesPhotoinduced electron transferFluorescence-lifetime imaging microscopyPyridiniumQuenching (fluorescence)BODIPYElectron transferOxygenMaterials scienceNanotechnologyOrganic chemistryQuantum mechanicsBiochemistryPhysicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies