STAT1 maintains naïve CD8 <sup>+</sup> T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
Yoon-Chul Kye, Gil-Woo Lee, Sungwoo Lee, Young-Jun Ju, Hee-Ok Kim, Cheol‐Heui Yun, Jae-Ho Cho
Abstract
STAT1 serves as a gatekeeper for naïve CD8 + T cell homeostasis by restraining type I IFN-STAT4-mTOR signaling axis.
Topics & Concepts
Cell biologyBiologySTAT1CD8T cellHomeostasisSTAT4mTORC1CD28InterferonSignal transductionCytotoxic T cellImmunologyImmune systemstatBiochemistryIn vitroSTAT3PI3K/AKT/mTOR pathwayT-cell and B-cell ImmunologyImmune Cell Function and Interactionmelanin and skin pigmentation