miR-129-5p Inhibits Bone Formation Through TCF4
Chong Yin, Ye Tian, Yang Yu, Chaofei Yang, Peihong Su, Yipu Zhao, Xue Wang, Kewen Zhang, Jiawei Pei, Dijie Li, Zhihao Chen, Yan Zhang, Zhiping Miao, Airong Qian
Abstract
. Moreover, novel recombinant miR-129-5p inhibitor showed rescue effect on osteoporosis. This study has revealed a new mechanism of osteogenic differentiation and provided novel therapeutic strategies for treatment of skeletal disorders.
Topics & Concepts
Bone formationTCF4ChemistryCell biologyMedicineCancer researchBiologyInternal medicineTranscription factorBiochemistryGeneEnhancerMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research