YTHDC2-mediated m6A mRNA modification of Id3 suppresses cisplatin resistance in non-small cell lung cancer
Xifan Wang, Yu’an Hu, Xiaoqing Li, Chuandong Zhu, Fangfang Chen
Abstract
Background: in controlling cisplatin resistance in non-small cell lung cancer (NSCLC). Methods: was clarified by m6A-immunoprecipitation-PCR (m6A-IP-PCR) assay. Results: mRNA. Conclusions: requires modifications to m6A, which ultimately inhibit cisplatin resistance in NSCLC.
Topics & Concepts
CisplatinA549 cellMolecular biologyCell growthFlow cytometryCancer researchApoptosisTransfectionMessenger RNACell cultureBiologyChemistryGeneBiochemistryGeneticsChemotherapyRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation