Fertility preservation in patients with BRCA mutation
Suleiman Ghunaim, Ghina Ghazeeri, Dalia Khalife, Hatem A. Azim
Abstract
Evidence suggests a likely negative impact of deleterious BRCA mutations on female fertility. Hence, different studies have aimed to address the reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients with a prime focus on their safety and efficacy. However, several uncertainties exist in many domains of this field. The aim of the current paper is to overview the reproductive potential and fertility preservation options in breast and ovarian cancer patients harbouring a BRCA mutation. We also discuss pre-implantation genetic testing in an attempt to help physicians during oncofertility counselling of these patients.
Topics & Concepts
OncofertilityFertility preservationFertilityMedicineBRCA mutationBreast cancerOncologyOvarian reserveGenetic counselingGynecologyGenetic testingInfertilityBioinformaticsCancerInternal medicinePopulationPregnancyGeneticsBiologyEnvironmental healthReproductive Biology and FertilityOvarian cancer diagnosis and treatmentBRCA gene mutations in cancer