Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue
Carlo Pifferi, Ane Ruiz‐de‐Angulo, David Goyard, Claire Tiertant, Nagore Sacristán, Diego Barriales, Nathalie Berthet, Juan Anguíta, Olivier Renaudet, Alberto Fernández‐Tejada
Abstract
cellular responses, with antibodies able to bind the Tn antigen on the MCF7 cancer cell surface. The superior synthetic accessibility and immunological properties of this fully-synthetic vaccine prototype makes it a compelling candidate for further advancement towards safe and effective synthetic anticancer vaccines.
Topics & Concepts
AdjuvantAntigenImmune systemAntibodyImmunologyVaccine adjuvantOximeTumor antigenChemistryImmunotherapyMedicineBiochemistryGlycosylation and Glycoproteins ResearchMonoclonal and Polyclonal Antibodies ResearchCarbohydrate Chemistry and Synthesis