Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast <i>In Vivo</i> NIR-II Imaging
Amélie Godard, Ghadir Kalot, Jacques Pliquett, Benoît Busser, Xavier Le Guével, K. David Wegner, Ute Resch‐Genger, Yoann Rousselin, Jean‐Luc Coll, Franck Denat, Ewen Bodio, Christine Goze, Lucie Sancey
Abstract
A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo. In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
Topics & Concepts
ChemistryFluorophoreIn vivoBiocompatible materialIn vitroWater solubleContrast (vision)FluorescenceNanotechnologyBiophysicsBiomedical engineeringBiochemistryOrganic chemistryOpticsBiotechnologyPhysicsMedicineBiologyMaterials scienceNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques