Photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles to impact ATP metabolism
Richard J. Mitchell, Dmytro Havrylyuk, Austin C. Hachey, David K. Heidary, Edith C. Glazer
Abstract
and photo-releasing a ligand exhibited the dominant profile of a PDT agent and induced the quiescent bioenergetic state, indicating potential implications on cellular bioenergetics for so-called dual-action agents. These findings are presented with the aim to provide the necessary groundwork for expanding the application and utility of EFA to phototherapeutics and to highlight the role of metabolic alterations in PDT.
Topics & Concepts
Photodynamic therapyBioenergeticsChemistryMetabolismPhotosensitizerAdenosine triphosphateCancer researchPharmacologyBiophysicsBiochemistryMedicineBiologyPhotochemistryMitochondrionOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism