Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway
Boshen Yang, Taixi Li, Zhixiang Wang, Yuankang Zhu, Kaifan Niu, Sien Hu, Zhiqi Lin, Xinjie Zheng, Xian Jin, Chengxing Shen
Abstract
This study highlighted the potential significance of cellular senescence in SCM pathogenesis and suggested Rux-based senomorphic therapy as a promising therapeutic approach for SCM.
Topics & Concepts
RuxolitinibCardiomyopathyMedicineSignal transductionSTAT3SenescencePharmacologyCancer researchInternal medicineCardiologyHeart failureCell biologyBiologyBone marrowMyelofibrosisSignaling Pathways in DiseaseCardiac Fibrosis and RemodelingAcute Myeloid Leukemia Research