Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors
Giuseppe Campiani, Caterina Cavella, J.D. Osko, Margherita Brindisi, Nicola Relitti, Simone Brogi, A. Prasanth Saraswati, Stefano Federico, Giulia Chemi, Samuele Maramai, Gabriele Carullo, Benedikt Jaeger, Alfonso Carleo, Rosaria Benedetti, Federica Sarno, Stefania Lamponi, Paola Rottoli, Elena Bargagli, Carlo Bertucci, Daniele Tedesco, Daniel Herp, Johanna Senger, Giovina Ruberti, Fulvio Saccoccia, Simona Saponara, Beatrice Gorelli, Massimo Valoti, Breandán N. Kennedy, Husvinee Sundaramurthi, Stefania Butini, Manfred Jung, Katy M. Roach, Lucia Altucci, Peter Bradding, David W. Christianson, Sandra Gemma, Antje Prasse
Abstract
was also determined in a validated human lung model of TGF-β1-dependent fibrogenesis. The results highlighted in this manuscript may pave the way for the identification of first-in-class molecules for the treatment of IPF.