Synthesis and Absolute Configuration of Habiterpenol
Miyuki Konya, Kenta Shimoyama, Shiho Arima, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda, Tohru Nagamitsu
Abstract
The synthesis of habiterpenol, a G2 checkpoint inhibitor, was achieved through the stereoselective Ti(III)-mediated radical cyclization of a β-epoxide as the key reaction. Moreover, the absolute configuration of habiterpenol was determined.
Topics & Concepts
ChemistryAbsolute configurationStereoselectivityEpoxideAbsolute (philosophy)StereochemistryCombinatorial chemistryOrganic chemistryCatalysisEpistemologyPhilosophyCancer Treatment and PharmacologyNatural product bioactivities and synthesisBiological Activity of Diterpenoids and Biflavonoids