Unveiling the anti-cancer mechanism for half-sandwich and cyclometalated Ir(<scp>iii</scp>)-based complexes with functionalized α-lipoic acid
Mengmeng Wang, Xuling Xue, Xi-Xi Sheng, Yan Su, Yaqiong Kong, Yong Qian, Jianchun Bao, Zhi Su, Hong‐Ke Liu
Abstract
) demonstrated that introduction of the LA ligand to Ir2 could highly enhance the cytotoxicity and help to overcome the cisplatin-resistance. This study of the half-sandwich and cyclometalated Ir(iii)-based anticancer agents highlighted the different MoAs toward cancer cells and provided new insights for understanding their structure-property relationships.
Topics & Concepts
Mechanism (biology)Lipoic acidCancerChemistryCombinatorial chemistryBiochemistryMedicinePhysicsInternal medicineAntioxidantQuantum mechanicsBiochemical Acid Research Studiesbiodegradable polymer synthesis and propertiesCarbon dioxide utilization in catalysis