Disruption of the gene regulatory programme in neurodevelopmental disorders
Aoife Griffin, Arun Mahesh, Vijay Tiwari
Abstract
Cortical development consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear that gene expression programs governing these events rely on the interplay between signalling molecules, transcription factors and epigenetic mechanisms. When genetic or environmental factors disrupt expression of genes involved in important brain development processes, neurodevelopmental disorders can occur. This review aims to highlight how recent advances in technologies have helped uncover and imitate the gene regulatory mechanisms commonly disrupted in neurodevelopmental disorders.
Topics & Concepts
EpigeneticsNeuroscienceBiologyTranscription factorGene regulatory networkGeneRegulation of gene expressionEpigenesisGene expressionComputational biologyDNA methylationGeneticsGenetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchPluripotent Stem Cells Research