FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer
Jinyuan Liu, Lei Xue, Xiang Xu, Jinhua Luo, Shijiang Zhang
Topics & Concepts
KRASCancer researchBiologyLung cancerProteasomeMutantFocal adhesionCancerCellMedicineCell biologyOncologyColorectal cancerBiochemistryGeneGeneticsProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways