Collaborative Activation of Trifluoroacetyl Diazoester by a Lewis Acid and Base for the Synthesis of Polysubstituted 4-Trifluoromethylpyrazoles
Zheng Fang, H. Yin, Lu Lin, Shunli Wen, Lili Xie, Yangjie Huang, Zhiqiang Weng
Abstract
-mediated cyclization of trifluoroacetyl diazoester and ketones is developed. Cooperative functioning of the Lewis acid and Lewis base with trifluoroacetyl diazoester results in increased electrophilicity of terminal nitrogen atoms. The reaction affords polysubstituted 4-trifluoromethyl pyrazoles in moderate to excellent yields.
Topics & Concepts
Lewis acids and basesElectrophileChemistryTrifluoromethylBase (topology)NitrogenMedicinal chemistryLewis acid catalysisOrganic chemistryCatalysisAlkylMathematicsMathematical analysisFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Reactions of Organic Compounds