Long-Term Effects of Developmental Exposure to Oxycodone on Gut Microbiota and Relationship to Adult Behaviors and Metabolism
Zhen Lyu, Robert Schmidt, Rachel E. Martin, Madison T. Green, Jessica A. Kinkade, Jiude Mao, Nathan J. Bivens, Trupti Joshi, Cheryl S. Rosenfeld
Abstract
exposure to an opioid drug can lead to longstanding effects on the gut microbiota when examined at adulthood. Further, such bacterial changes are associated with metabolic host responses. Given the similarities between rodent and human microbiomes, it raises cause for concern that similar effects may become evident in children born to mothers taking oxycodone and other opioid drugs.
Topics & Concepts
Gut floraTerm (time)MetabolismBiologyPhysiologyEndocrinologyImmunologyQuantum mechanicsPhysicsDiet and metabolism studiesGut microbiota and healthMaternal Mental Health During Pregnancy and Postpartum