Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages
Yinghong Zheng, Jiayuan Kou, Pengyu Wang, Ting Ye, Zitong Wang, Ziyu Gao, Lin Cong, Manman Li, Bowen Dong, Wei Yang, Quanfeng Li, Hong Li, Rui Wang, Liming Yang
Abstract
synthesis pathway and, in turn, promoting TFEB nuclear translocation and deacetylation. The functional regulation of SIRT1 and TFEB by berberine could be exploited as a potential therapeutic strategy for atherosclerosis.
Topics & Concepts
AutophagyTFEBAcetylationBerberineChemistryCell biologyCancer researchMedicineBiochemistryBiologyApoptosisGeneAutophagy in Disease and TherapyCannabis and Cannabinoid ResearchBerberine and alkaloids research