Electrochemical Selenium-Catalyzed <i>N,O</i>-Difunctionalization of Ynamides: Access to Polysubstituted Oxazoles
Jun‐Qi Zhang, Chunjiao Shen, Shihao Shuai, Ling Fang, Dandan Hu, Jiali Wang, Yu Zhou, Bukuo Ni, Hongjun Ren
Abstract
A green and efficient approach for the difunctionalization of ynamides by merging the electrochemical and organoselenium-catalyzed processes is described. This strategy features mild reaction conditions, broad functional group tolerance and high atom-economy, and requires no external chemical oxidant. Hence, we provide a sustainable alternative for the synthesis of polysubstituted oxazoles.
Topics & Concepts
ChemistryCatalysisSeleniumAtom economyElectrochemistryCombinatorial chemistryAtom (system on chip)Organic chemistryComputer scienceEmbedded systemElectrodePhysical chemistryCatalytic Alkyne ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods