SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling
Nathaniel Robinson, Masaru Miyagi, Jessica Scarborough, Jacob G. Scott, Derek J. Taylor, William P. Schiemann
Abstract
expression, which promoted Notch signaling and the institution of ALT. This axis could be targeted therapeutically in ALT-driven cancers and in tumor cells that develop resistance to antitelomerase therapies. Our results illuminate the mechanisms underlying SLX4IP-dependent telomere plasticity and demonstrate the role of telomere proteins in directly coordinating intracellular signaling and telomere maintenance dynamics.
Topics & Concepts
Notch signaling pathwaySUMO proteinCell biologyTelomereRap1Signal transductionNF-κBBiologyCancer researchChemistryUbiquitinGeneticsDNAGeneTelomeres, Telomerase, and SenescenceRNA modifications and cancer