Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R<sub>p</sub>- and S<sub>p</sub>-dNTPαS Diastereomers
E.R. Morris, Simone Kunzelmann, Sarah J. Caswell, Andrew G. Purkiss, Geoff Kelly, Ian A. Taylor
Abstract
-dNTPαS nucleotides that competes with formation of the enzyme-substrate complex.
Topics & Concepts
SAMHD1ChemistryNucleotideDiastereomerStereochemistryDeoxyribonucleotideBiochemistryRNAReverse transcriptaseGeneinterferon and immune responsesCytokine Signaling Pathways and InteractionsHepatitis C virus research