Pyrrolizine/indolizine-bearing (un)substituted isoindole moiety: design, synthesis, antiproliferative and MDR reversal activities, and <i>in silico</i> studies
Amr L. AbdelSamad, Mohammed T. El‐Saadi, Ahmed M. Gouda, Asmaa M. AboulMagd
Abstract
22.27, 3.88, and 8.79 μM, respectively. Moreover, the apoptotic activity of the most active derivative 6o on HCT-116 cancer cells showed accumulation in the G1 and S phases of the cell cycle.
Topics & Concepts
ChemistryMoietyStereochemistryIndolizineIC50DoxorubicinCell cultureCell growthBiochemistryIn vitroChemotherapyMedicineSurgeryBiologyGeneticsCancer therapeutics and mechanismsSynthesis and Reactivity of HeterocyclesBioactive Compounds and Antitumor Agents