Ca <sup>2+</sup> signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG
Aurélia C. Balestra, Konstantinos Koussis, Natacha Klages, Steven Howell, Helen R. Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J. Perrin, Lorenzo Brusini, Patrizia Arboit, Olalla Sanz, Laura Peces-Barba Castaño, Chrislaine Withers‐Martinez, Alexandre Hainard, Sonja Ghidelli‐Disse, Ambrosius P. Snijders, David A. Baker, Michael J. Blackman, Mathieu Brochet
Abstract
ICM1 is detrimental for the parasite resulting in severely reduced calcium mobilization, defective egress, and lack of invasion. Our findings suggest that ICM1 is a key missing link in transducing PKG-dependent signals and provide previously unknown insights into atypical calcium homeostasis in malaria parasites essential for pathology and disease transmission.
Topics & Concepts
GametogenesisMalariaCell biologyBiologyPhysicsImmunologyCryopreservationEmbryoMalaria Research and ControlInsect Resistance and GeneticsMosquito-borne diseases and control