A Golden Touch in the Design of Multifunctional Porphyrin Metallacages: Host–Guest Chemistry for Drug-Target Interactions
Tamara Rodríguez-Prieto, Darren Wragg, Nicole Heiduk, Mihyun Park, Nicole Strittmatter, Roland A. Fischer, Angela Casini, Guillermo Moreno‐Alcántar
Abstract
Open AccessCCS ChemistryCOMMUNICATIONS3 Apr 2024A golden touch in the design of multifunctional porphyrin metallacages: Host-guest chemistry for drug-target interactions. Tamara Rodríguez-Prieto, Darren Wragg, Nicole Heiduk, Mihyun Park, Nicole Strittmatter, Roland A. Fischer, Angela Casini and Guillermo Moreno-Alcántar Tamara Rodríguez-Prieto , Darren Wragg , Nicole Heiduk , Mihyun Park , Nicole Strittmatter , Roland A. Fischer , Angela Casini and Guillermo Moreno-Alcántar https://doi.org/10.31635/ccschem.024.202404056 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail The use of three-dimensional self-assembled metallacages (MCgs) as multimodal drug platforms holds great promise. However, the synthesis of MCgs with increased complexity and functionality is a great challenge, and knowledge of the interaction of MCgs with biological targets is still lacking. In this context, this work reports on the integration of a gold(III) porphyrin scaffold into a prismatic metallacage structure and explores its application for multimodal therapy of cancer in vitro, namely enabling both photodynamic therapy (PDT) and chemotherapy activity. Combining experimental approaches with a state-of-the-art metadynamics (MetaD) theoretical study, we discovered that the gold cage shows unprecedented host-guest interactiondriven selective stabilization of guanine-quadruplexes (G4) structures - validated anticancer drug targets - disclosing a new mechanism to pursue in the design of supramolecular drugs. Download figure Download PowerPoint Previous articleNext article FiguresReferencesRelatedDetails Issue AssignmentNot Yet AssignedSupporting Information Copyright & Permissions© 2024 Chinese Chemical Society Downloaded 0 times PDF downloadLoading ...