Epigenetic modifications of gut microbiota and their potential role in atherosclerosis
Shuang Guo, Junlai Zhao, Rongrong Zhu, Zhi Fan, Shibiao Liu, Weiwei Wu
Abstract
Emerging evidence positions the gut microbiota as a pivotal regulator of host metabolism and immunity, particularly in atherosclerosis pathogenesis, with epigenetic mechanisms serving as fundamental mediators of gene expression control. This review systematically summarizes gut microbiome-driven epigenetic pathways, encompassing DNA methylation, histone modifications, non-coding RNA networks and their interplay with atherosclerosis-related pathological processes. We synthesize current evidence on microbiota-epigenome crosstalk, highlighting its potential mechanistic contributions to atherosclerotic plaque development.
Topics & Concepts
EpigenomeEpigeneticsBiologyCrosstalkDNA methylationHistoneMicrobiomeGut floraEpigenomicsRegulatorGeneticsComputational biologyCell biologyBioinformaticsImmunologyGeneGene expressionOpticsPhysicsEpigenetics and DNA MethylationGut microbiota and healthRNA modifications and cancer