SYNTHESIS, STRUCTURAL CHARACTERIZATION OF SOME PYRAZOLO [1-5A] PYRIMIDINE AND IMIDAZO[1,2-B]- PYRAZOLE DERIVATIVES AS ANTI-CANCER ACTIVITY
Usama Fathy, Ameen A. Abu‐Hashem, Rasha S. Gouhar, Hanem M. Awad, Abdelbaset M. Elgamal
Abstract
For anticancer cell line evaluation, a new sequence of pyrazolo [1-5a] pyrimidine and imidazo[1,2-b] pyrazole derivatives were synthesized. The reaction of 5-aminopyrazolo with appropriate functionalized enaminones derivatives and 2-bromoacetophenone to afford, respectively. In vitro tests were performed on the newly synthesized compounds against HepG-2 and MCF-7 cancer cells to assay their cytotoxicity. A few compounds showed promising activity as anticancer agents against MCF-7 cancer cell.
Topics & Concepts
PyrazolePyrimidineCytotoxicityChemistryIn vitroCancer cell linesCombinatorial chemistryCancer cellStereochemistryCancerBiochemistryMedicineInternal medicineSynthesis and biological activitySynthesis of Tetrazole DerivativesSynthesis and Biological Evaluation