Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors
Edward Grimley, Alexander J. Cole, Thong Luong, Stacy McGonigal, Sarah Sinno, Dongli Yang, Kara A. Bernstein, Ronald J. Buckanovich
Abstract
: ALDHi can be used to induce DNA DSB in cancer cells and synergize with inhibitors the ATM/ATR pathway. Our data suggest a novel therapeutic approach to target HR proficient ovarian cancer cells.
Topics & Concepts
Aldehyde dehydrogenaseDNA damageDNA repairALDH2In vivoChemistryComet assayCancer cellMolecular biologyBiochemistryCancer researchDNABiologyEnzymeCancerGeneticsDNA Repair MechanismsGenomics, phytochemicals, and oxidative stressPARP inhibition in cancer therapy