On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity
Fatma Elrashdy, Abdullah A. Aljaddawi, Elrashdy M. Redwan, Vladimir N. Uversky
Abstract
We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
MicrovesiclesExtracellular vesiclesExtracellularCoronavirus disease 2019 (COVID-19)VirologyExtracellular vesicleExosomeCell biologyRNABiologyVesicleMedicineGeneticsmicroRNAMembraneInfectious disease (medical specialty)PathologyDiseaseGeneExtracellular vesicles in diseaseSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies