Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression
Kuo Zhang, Fan Wang, Mengying Zhai, Mei-yao He, Yuxuan Hu, Lijin Feng, Yuting Li, H. J. Yang, Chunfu Wu
Abstract
Our findings reveal a neuronal autophagy-dependent mechanism that links chronic CORT to reduced neuronal BDNF levels, AHN suppression and depressive-like behavior in mice. In addition, our results provide insights for treating depression by targeting neuronal autophagy in the DG of the hippocampus.
Topics & Concepts
NeurogenesisDentate gyrusNeural stem cellHippocampal formationAutophagyNeurotrophic factorsHippocampusATG5BiologyCell biologyNeuroscienceEndocrinologyInternal medicineStem cellMedicineApoptosisBiochemistryReceptorNeurogenesis and neuroplasticity mechanismsNerve injury and regenerationNeuroinflammation and Neurodegeneration Mechanisms