The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease
Nathanael D. Reynolds, Nathalie M. Aceves, Jinny L. Liu, Jaimee R. Compton, Dagmar H. Leary, Brendan T. Freitas, Scott D. Pegan, Katarina Z. Doctor, F.Y. Wu, Xin Hu, Patricia M. Legler
Abstract
. Other patterns emerged from multispecies sequence alignments of the cleavage sites, which may have implications for the selection of animal models and zoonosis. SSHHPS/nsP is an example of a sequence-specific post-translational silencing mechanism.
Topics & Concepts
ProteasesBiologyProteaseVirologyNS2-3 proteasePeptide sequenceViral structural proteinCleavage (geology)VirusViral entryViral replicationGeneticsGeneBiochemistryEnzymeFracture (geology)PaleontologySARS-CoV-2 and COVID-19 Researchinterferon and immune responsesAnimal Virus Infections Studies