Multiscale structural design of MnO2@GO superoxide dismutase nanozyme for protection against antioxidant damage
Yue Yu, Yinuo Zhang, Yu Wang, Wenxing Chen, Zhanjun Guo, Ningning Song, Minmin Liang
Abstract
Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase (SOD) nanozymes. Here, we reported a novel SOD nanozyme design, with employing graphene oxide (GO) as the framework, and δ-MnO2 as the active sites, to mimic the natural Mn-SOD. This MnO2@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology, providing highly specific surface area for ·O 2 − adsorption and confined spaces for subsequent catalytic reactions. Thus, the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%, which is 222.6% and 1605.4% amplification over GO and MnO2 nanoparticles, respectively. Additionally, such unique hierarchical structural design endows MnO2@GO with catalytic specificity, which was not present in the individual component (GO or MnO2). This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes.