Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer
Fangyuan Guo, Nan Yu, Yunlong Jiao, Weiyong Hong, Kang Zhou, Xugang Ji, Huixing Yuan, Haiying Wang, Aiqin Li, Guoping Wang, Gensheng Yang
Abstract
results illustrated that (DOX + CUR)-FA-NPs not only displayed significant tumor targeting and anticancer efficacy, but also induced less pathological damage to the normal tissue. In summary, co-administered DOX and CUR appeared to reverse MDR, and this targeted combinational nanoscale delivery system could thus be a promising carrier for tumor therapies in the future.
Topics & Concepts
CurcuminDoxorubicinPharmacologyMultiple drug resistanceIn vivoCancer cellApoptosisDrug deliveryMedicineCancer researchCancerMaterials scienceChemistryChemotherapyNanotechnologyBiologyBiochemistryAntibioticsInternal medicineBiotechnologyNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsRNA Interference and Gene Delivery