The Bacillus anthracis Cell Envelope: Composition, Physiological Role, and Clinical Relevance
Alice Château, Sander E. Van der Verren, Han Remaut, Antonella Fioravanti
Abstract
Anthrax is a highly resilient and deadly disease caused by the spore-forming bacterial pathogen Bacillus anthracis. The bacterium presents a complex and dynamic composition of its cell envelope, which changes in response to developmental and environmental conditions and host-dependent signals. Because of their easy to access extracellular locations, B. anthracis cell envelope components represent interesting targets for the identification and development of novel therapeutic and vaccine strategies. This review will focus on the novel insights regarding the composition, physiological role, and clinical relevance of B. anthracis cell envelope components.
Topics & Concepts
Bacillus anthracisEnvelope (radar)BiologyMicrobiologyCell envelopePathogenIdentification (biology)Cell biologyComputational biologyBacteriaBiochemistryGeneticsComputer scienceEcologyGeneTelecommunicationsRadarEscherichia coliBacillus and Francisella bacterial researchBacteriophages and microbial interactionsBacterial Genetics and Biotechnology