The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
Betty Diamond
Abstract
The renin-angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has not been explored fully as a druggable target. The abbreviated description of the RAS suggests that its dysregulation may be at the center of COVID-19.
Topics & Concepts
Renin–angiotensin systemCoagulopathyDruggabilityCoronavirus disease 2019 (COVID-19)MedicineDiseasePeptidyl-Dipeptidase AMechanism (biology)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Blood pressure2019-20 coronavirus outbreakIntensive care medicineImmunologyInfectious disease (medical specialty)Internal medicineVirologyBiologyEpistemologyBiochemistryGenePhilosophyOutbreakCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19