Hepcidin's Antimalarial Arsenal: Safeguarding the Host
Emmanuel Ifeanyi Obeagu, Esther Ugo Alum, Okechukwu Paul-Chima Ugwu
Abstract
Malaria remains a significant global health threat, causing hundreds of thousands of deaths annually. Understanding the host's protective mechanisms against this parasitic infection is crucial for developing effective prevention and treatment strategies. Hepcidin, a central regulator of iron homeostasis, has emerged as a key player in the host's defense against malaria. This comprehensive review explores the multifaceted roles of hepcidin in safeguarding the host from malaria infection. We delve into the molecular mechanisms of hepcidin regulation and its impact on the intricate interplay between iron, the immune system, and Plasmodium species. Additionally, we discuss the potential therapeutic implications of targeting hepcidin to enhance antimalarial responses. By shedding light on hepcidin's antimalarial arsenal, this review aims to contribute to the development of innovative strategies for combating malaria. Keywords: Hepcidin, antimalaria, malaria and host