Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes
Mayumi K. Holly, Xiao Han, Edward Zhao, Shauna M. Crowley, Joannie M. Allaire, Leigh A. Knodler, Bruce A. Vallance, Jason G. Smith
Abstract
Recent studies have determined that inflammasome signaling plays an important role in driving intestinal epithelial cell (IEC) responses to bacterial infections, such as Salmonella enterica serovar Typhimurium. There are two primary inflammasome pathways, canonical (involving caspase-1) and noncanonical (involving caspase-4 and -5 in humans and caspase-11 in mice). Prior studies identified the canonical inflammasome as the major pathway leading to interleukin-18 (IL-18) release and restriction of S .
Topics & Concepts
InflammasomeSalmonella entericaBiologySalmonellaMicrobiologyCaspase 1Signal transductionCaspaseIntestinal epitheliumCell biologyApoptosisEpitheliumImmunologyProgrammed cell deathInflammationBacteriaGeneticsInflammasome and immune disordersPhagocytosis and Immune RegulationImmune Response and Inflammation