CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3/NF-κB/SDF-1α axis to enhance efficacy against pancreatic cancer
Ruixin Sun, Yansha Sun, Chuanlong Wu, Yifan Liu, Min Zhou, Dong Yiwei, Guoxiu Du, Hong Luo, Bizhi Shi, Hua Jiang, Zonghai Li
Topics & Concepts
Cancer researchStromal cellPancreatic cancerTumor microenvironmentSTAT3Chimeric antigen receptorCXCR4Cancer cellTumor necrosis factor alphaCancerMedicineT cellInflammationBiologySignal transductionImmunologyChemokineCell biologyImmune systemInternal medicineTumor cellsCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction