The renoprotective effect of curcumin against cisplatin-induced acute kidney injury in mice: involvement of miR-181a/PTEN axis
Sijia Huang, Jing Huang, Yunbo Yan, Jiao Qiu, Rui-Qiao Tan, Yu Liu, Qing Tian, Li Guan, Shuaishuai Niu, Yanxiang Zhang, Zhijiang Xi, Ying Xiang, Quan Gong
Abstract
We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.
Topics & Concepts
CurcuminCisplatinPTENNephrotoxicityMedicinePharmacologyAcute kidney injuryTensinKidneyApoptosisInternal medicinePI3K/AKT/mTOR pathwayChemistryChemotherapyBiochemistryChemotherapy-induced organ toxicity mitigationRenal and related cancersAcute Lymphoblastic Leukemia research