Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update
Mathieu Bellal, Jolan Malherbe, Gandhi Damaj, Damien du Cheyron
Abstract
BACKGROUND: Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are associated with severe life-threatening toxicities and side effects that may require admission to ICU. OBJECTIVE: The aim of this short pragmatic review is to synthesize for intensivists the knowledge on CAR-T cell therapy with emphasis on CAR-T cell-induced toxicities and ICU management of complications according to international recommendations, outcomes and future issues.
Topics & Concepts
Chimeric antigen receptorMedicineImmunotherapyRefractory (planetary science)Intensive care medicineIntensive careAntigenImmunologyImmune systemPhysicsAstrobiologyCAR-T cell therapy researchAdvancements in Semiconductor Devices and Circuit DesignNanowire Synthesis and Applications