Lithium compound catalyzed deoxygenative hydroboration of primary, secondary and tertiary amides
Milan Kumar Bisai, Kritika Gour, Tamal Das, Kumar Vanka, Sakya S. Sen
Abstract
A selective and efficient route for the deoxygenative reduction of primary to tertiary amides to corresponding amines has been achieved with pinacolborane (HBpin) using simple and readily accessible 2,6-di-tert-butyl phenolate lithium·THF (1a) as a catalyst. Both experimental and DFT studies provide mechanistic insight.
Topics & Concepts
HydroborationLithium (medication)Primary (astronomy)ChemistryCatalysisOrganic chemistryTertiary alcoholsEndocrinologyMedicineAstronomyPhysicsOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic Chemistry